Maintenance of cutaneous functions and level of skin hydration by lactic acid bacteria metabolites.
This in vivo study evaluated on atopic dermatitis-like hairless rat model the effects of 0.3 mL of lactic acid bacteria metabolites supplementation during 28 days on water content in the stratum corneum, transepidermal water loss (TEWL), ceramide AP content in the stratum corneum, and epidermis thickness.
Transepidermal water loss (TEWL) and water content of stratum corneum in normal rats (Normal), atopic dermatitis-like hairless rat model (Control) and atopic dermatitis-like hairless rat model treated with lactic acid bacteria metabolites (LFP). *** p < 0.001 (Tukey’s post-hoc test).
After supplementation, all measured parameters were improved in atopic dermatitis-like hairless rat model. Author also evaluated components responsible for these effects and showed that water-soluble components and residue obtained after filtration had no effects, whereas the lipid fraction showed similar effects to the raw liquid.
In conclusion, lactic acid bacteria metabolites, localized in the lipid fraction, improve skin injury in an atopic dermatitis-like murine model.
Tokudome Y. Influence of Oral Administration of Lactic Acid Bacteria Metabolites on Skin Barrier Function and Water Content in a Murine Model of Atopic Dermatitis. Nutrients 2018, 10(12), 1858.