Saffron supplementation in patients with allergic asthma decreases significantly anti-heat shock proteins 70 and high-sensitivity C-reactive protein.

The aim of this triple-blind, randomized placebo-controlled trial was to survey the effect of saffron supplementation on anti-HSP70, high-sensitivity C-reactive protein (hs-CRP) and spirometry test in patients with allergic asthma.

To do so, 80 patients with mild and moderate allergic asthma were randomized to receive either two capsules of saffron (100 mg/d) or placebo (control group) for 8 weeks.

Saffron supplementation in patients with allergic asthma

Within- and between-group comparisons of the changes from baseline to endpoint measures for hs-CRP and anti-HSP70 in saffron and placebo groups of asthmatic patients

Results showed that saffron significantly reduced the hs-CRP (p < 0.001) and anti-HSP70 (p < 0.001) concentrations compared to placebo. In spirometry test, forced expiratory volume in first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio and forced expiratory flow were 25-75%. (FEF 25-75) increased significantly in saffron in comparison to placebo group (p < 0.05).

Authors concluded that saffron supplementation in patients with allergic asthma decreased significantly anti-HSPs 70 and hs-CRP and also improved some spirometry test factors.

Hosseini SA, Zilaee M, Shoushtari MH, Ghasemi Dehcheshmeh M. An evaluation of the effect of saffron supplementation on the antibody titer to heat-shock protein (HSP) 70, hsCRP and spirometry test in patients with mild and moderate persistent allergic asthma: A triple-blind, randomized placebo-controlled trial. Respir Med. 2018 Dec; 145:28-34.

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