This double-blind, randomized, placebo-controlled study, evaluated among 92 patients with non-alcoholic fatty liver disease (NAFLD) the effects of supplementation with either 3 g/d of turmeric or 9 g/d of infused chicory seed (4.5 g /100mL) or both turmeric and chicory seed or a placebo during 12 weeks.

At the end of the supplementation period, results showed a significant decrease in body mass index and waist circumference in chicory and mixture groups (p < 0.05 vs. placebo). Combination of turmeric and chicory seed significantly decreased serum alkaline phosphatase level (p < 0.05). Serum levels of HDL-Cholesterol increased considerably in turmeric and mixture groups (p < 0.05 vs. placebo). Moreover, turmeric and mixture supplementations led to significant reduction in serum levels of triglycerides/HDL-Cholesterol and LDL-Cholesterol/HDL-Cholesterol ratio (p < 0.05 vs. placebo).

In conclusion, turmeric and chicory seed supplementation can be significantly useful in management of NAFLD risk factors.

Ghaffari A, Rafraf M, Navekar R, Sepehri B, Asghari-Jafarabadi M, Ghavami SM. Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD). Int J Vitam Nutr Res. 2019 Apr 24:1-10.