The aim of this study was to examine whether a lycopene supplementation can improve the spermatogram of infertile men with oligozoospermia. 44 men have been enrolled. The study was randomized, double blinded and placebo-controlled. The experimental group received 25 mg/day of lycopene.

After 12 weeks of supplementation, significant increases in total sperm count and sperm concentration have been measured in the lycopene group. Moreover, in comparison to baseline, lycopene also increased ejaculate volume, total sperm count, sperm concentration and total motility. Total antioxidant capacity has also been affected by the supplementation.

Therefore, lycopene may improve fertility in infertile men with oligozoospermia, possibly by modulating oxidative stress.

Nouri M, Amani R, Nasr-Esfahani M, Tarrahi MJ. The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2019 Aug 30.