This prospective, randomized, controlled and open label trial investigated the serum level of 25 hydroxy vitamin D in acne patients and to assess the efficacy and safety of active vitamin D in management of acne. 100 patients with acne received either the 0.25ug alfacalcidol/d or the placebo group during 3 months, they also were compared to 100 healthy patients.

Serum levels of 25-hydroxy-vitamin D were significantly lower in acne patients than in healthy control and were inversely correlated to the severity of acne. After supplementation the study group showed significant higher level of 25(OH) D levels (P <0.05) median serum level of IL6 and TNFalpha significantly decreased (p < 0.05) compared to placebo group. In addition, study group showed improvement (p<0.05) in the acne severity (GAGS scale) as compared their baseline results. They were no adverse events. 

Those results showed that alfacalcidol might have a beneficial role in the acne management with no reported side effects.

Amal Ahmed Mohamed, Eman Mohamed Salah Ahmed, Rasha TA AbdelAziz, Halaa H. Eldeeb Abdallah, Hadeel El-Hanafi, Ghada Hussein, Maggie M. Abbassi & Radwa El boroloss. Informative title: “The Impact of Active Vitamin D Administration on the Clinical outcomes of Acne Vulgaris”. Journal of Dermatological Treatment. 2020 Jan 21:1.