This double-blinded, randomized, and placebo-controlled study examined the effects of a sage extract (300 mg/day for 3 months) in postmenopausal women complaining of menopausal symptoms. 66 women have been enrolled. The authors used the Menopause Rating Scale (MRS° and the Pittsburgh Sleep Quality Index (PSQI) to assess the effects of the supplementation.

Results showed a reduction in the scores of the MRS for flushing, palpitation, sleeping disorders, muscle and joint aches, depression, nervousness, anxiety and sexual desire/satisfaction in the supplemented group in comparison to placebo (p < 0.001 for all). In addition, the mean PSQI score has been also reduced by the supplementation, highlighting a significant improvement in sleep.

These results suggest therefore sage extract may be used for the management of menopausal symptoms and menopause-associated sleep disorders.

Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. J Family Med Prim Care. 2020 Feb 28;9(2):1086-1092.