This meta-analysis compiled data from 50 clinical trials assessing the metabolic effects of Nigella sativa supplementations. The authors reported a significant effect of N. sativa on total cholesterol, triglycerides, LDL-cholesterol and VLDL-cholesterol. In addition, reductions were also noted in fasting blood glucose and HbA1c levels.

Therefore, this meta-analysis showed that N. sativa supplementations can have beneficial effects on blood lipids and glucose control, highlighting a potential anti-diabetic properties of black cumin, as a possible reduction in cardiovascular disease risk.

Hallajzadeh J, Milajerdi A, Mobini M, Amirani E, Azizi S, Nikkhah E, Bahadori B, Sheikhsoleimani R, Mirhashemi SM. Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2020 May 11. doi: 10.1002/ptr.6708. [Epub ahead of print]