COVID-19 can have severe, possibly persisting consequences, like endothelial dysfunction, microcirculatory problems, coagulopathy, cytokine storm and capillary leak syndrome. In various clinical studies, Pycnogenol® revealed positive effects relating to conditions that are also present in SARS-CoV2 infections.

Pycnogenol® improves endothelial health and microcirculation, normalizes platelet reactivity and shows anti-inflammatory effects. Therefore, in this review, authors hypothesize possible additional beneficial effects of Pycnogenol® in patients infected with the new coronavirus SARS-CoV2 and those who suffer from abiding health problems, when complemented to the standard treatment also upon the first day of symptoms or infection.

Weichmann F, Rohdewald P. Projected supportive effects of Pycnogenol® in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection. Int J Antimicrob Agents. 2020 Oct 9:106191.