COVID‐19 is spreading worldwide, leading a pandemic. This review highlighted that curcumin could be a new treatment option to combat the COVID‐19. Curcumin, an active constituent of Curcuma longa (turmeric), has some useful clinical effects such as antiviral, antinociceptive, anti‐inflammatory, antipyretic, and antifatigue effects that could alleviate symptoms of the infected patient with COVID‐19. Curcumin could reduce inflammatory cytokines via inhibiting TLR/MAPK/NF‐κB signaling. Curcumin might attenuate acute respiratory distress syndrome and pulmonary fibrosis due to anti‐inflammatory properties.
Babaei F, Nassiri-Asl M, Hosseinzadeh H. Curcumin (a constituent of turmeric): New treatment option against COVID-19. Food Sci Nutr. 2020 Sep 6;8(10):5215-5227. doi: 10.1002/fsn3.1858. PMID: 33133525; PMCID: PMC7590269.
Tea and Coffee
The global spread of COVID 19 is ongoing and the natural polyphenols are catching more attention in the management of this pandemic. The protease inhibitor is one of the key challenges. Metabolic profiling of leaves methanolic extract of Ficus microcarpa (Moraceae) revealed nine compounds mainly phenolics and the docking studies of these compounds against SARS-CoV-2 main protease showed that quercetin 3,7-O-α-L-dirhamnoside and rutin possessed significant binding stability at the N3 binding site in different activity degrees, which is comparable with COVID-19 main protease inhibitor, darunavir. These results highlight the potential of Ficus microcarpa metabolites against SARA-CoV-2. (Hassan et al., 2020).
Constantly, a review proposed that the intake of polyphenols present in coffee and tea may have potential positive effects as an adjuvant therapy in patients with metabolic disorders, such as diabetes and metabolic syndrome. However, this seems not to be elucidated enough. Further studies are warranted to confirm these beneficial properties (Semiz et al., 2020).
Hassan HA, Abdelmohsen UR, Aly OM, Desoukey SY, Mohamed KM, Kamel MS. Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies. Nat Prod Res. 2020 Oct 30:1-5. doi: 10.1080/14786419.2020.1839452. Epub ahead of print. PMID: 33121282.
Semiz S, Serdarevic F. Prevention and Management of Type 2 Diabetes and Metabolic Syndrome in the Time of COVID-19: Should We Add a Cup of Coffee? Front Nutr. 2020 Oct 6;7:581680. doi: 10.3389/fnut.2020.581680. PMID: 33123550; PMCID: PMC7573071.
Like other coronaviruses (CoV2) infection, prenatal COVID infection is anticipated to affect fetal development by maternal inflammatory response on the fetus and placenta. This in silico study demonstrated that the essential nutrient Choline has effect on neuroprotective immunity for the prevention of SARS CoV2 infections. The virtual screening, molecular docking and molecular dynamics techniques showed a strong inhibitory possibility of choline for SARS 3CL protease which is a key enzyme responsible for replication and transcription function for SARS CoV2 (Chowdhury et al., 2020).
The study suggested Choline as a strong candidate inhibitor for SARS-CoV2 which would provide a lead for the prenatal drug development for the treatment of COVID-19.
Chowdhury P, Pathak P. Neuroprotective Immunity by Essential Nutrient “Choline” for the Prevention of SARS CoV2 Infections: An In Silico Study by Molecular Dynamics Approach. Chem Phys Lett. 2020 Oct 3;761:138057. doi: 10.1016/j.cplett.2020.138057. Epub ahead of print. PMID: 33041350; PMCID: PMC7532804.