Peptides derived from certain probiotic strains exhibit a beneficial effect in the regulation of infection with the SARS-CoV-2 virus in silico

This study has evaluated the effects in silico of different lipopetides from different probiotic strains (subtilisin (Bacillus amyloliquefaciens), curvacin A (Lactobacillus curvatus), sakacin P (Lactobacillus sakei), lactococcin Gb (Lactococcus lactis)) on the inactivation of spike (S) glycoprotein of SARS-CoV-2 and its host receptor molecule, ACE2.

The outcome revealed noteworthy capabilities of the lipopeptides, due to their amphiphilic nature, to bind spike protein and receptor molecule, which may act to competitively inhibit the mandatory interaction of SARS-CoV-2 with the host epithelial cell expressing ACE2 for its entry into the cell for reproduction.

In conclusion, probiotics may aid towards building up the immune defenses in people to evade COVID-19.

Interaction of lipopeptide, subtilisin-hACE2 complex with S1 protein. hACE2-subtilisin complex docked with SARS-CoV-2 (S protein)

Manna S, Chowdhury T, Chakraborty R, Mandal SM. Probiotics-Derived Peptides and Their Immunomodulatory Molecules Can Play a Preventive Role Against Viral Diseases Including COVID-19. Probiotics Antimicrob Proteins. 2020 Nov 23. doi: 10.1007/s12602-020-09727-7. Epub ahead of print. PMID: 33226581.

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