In this placebo controlled randomized triple blind study, 75 patients with functional dyspepsia received either a combination of 500 mg curcumin and 40 mg famotidine daily or placebo and 40 mg famotidine for 1 month. The severity of dyspepsia symptoms and the presence of Helicobacter pylori have been assessed in participants.
A significant decrease was observed in severity of dyspepsia (p < 0.001) and rate of H. pylori infection (p = 0.004) immediately after the treatment and follow-up in the curcumin intervention group.
This study indicated that curcumin therapy could be a favorable supplementation in the symptom management of functional dyspepsia.
Panahi Y, Karbasi A, Valizadegan G, Ostadzadeh N, Soflaei SS, Jamialahmadi T, Majeed M, Sahebkar A. Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial. Adv Exp Med Biol. 2021;1308:119-126.