This pilot study, double-blinded, placebo-controlled and randomized, examined the prophylactic effect of neem in patients at risk of COVID-19 infection due to contact with COVID-19 positive patients. 190 participants have been enrolled. They received a placebo or 50 mg twice daily of a neem leaf extract for 28 days.
Among the 154 participants who completed the study, 3 were tested positive in the supplemented group, whereas 8 were tested positive in the placebo group. The risk of infection was 0.45 times the risk of participants in the placebo group.
Therefore, this pilot study suggest that neem leaf extract (Azadirachta indica) may have prophylactic effect on COVID-19 infection in subjects in contact with COVID-19 positive patients.
Doaei S, Gholami S, Rastgoo S, Gholamalizadeh M, Bourbour F, Bagheri SE, Samipoor F, Akbari ME, Shadnoush M, Ghorat F, Mosavi Jarrahi SA, Ashouri Mirsadeghi N, Hajipour A, Joola P, Moslem A, Goodarzi MO. The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial. J Transl Med. 2021 Mar 29;19(1):128.