This randomized double-blind, placebo-controlled trial was conducted on 84 women (age 18-40 years) with polycystic ovary syndrome (PCOS) receiving magnesium (250 mg), melatonin (6 mg), magnesium plus melatonin, or placebo for 8 weeks.
Results show that magnesium-melatonin co-supplementation resulted in more reductions in hirsutism (stiff or dark body hair, appearing on the body where women don’t commonly have hair [face, chest, abdomen…]) compared with other groups (p < 0.001). Serum levels of TNF-alpha declined significantly in the melatonin and co-supplementation groups compared to baseline (p < 0.05). Also, magnesium plus melatonin was associated with higher increase in total antioxidant capacity levels, as compared to the other treatment groups (p = 0.001).
In conclusion there is a favorable effect of co-supplementation of magnesium and melatonin in women with PCOS on hirsutism, inflammation and oxidative stress levels.
Mousavi R, Alizadeh M, Asghari Jafarabadi M, Heidari L, Nikbakht R, Babaahmadi Rezaei H, Karandish M. Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res. 2021 May 19.