This randomized, double-blind, placebo-controlled study aimed to evaluate the safety and efficacy of Physta® on the testosterone levels and quality of life in ageing male subjects (n = 105). Participants received either Physta® 100 mg, 200 mg or placebo daily for 12 weeks. Results showed that a significant increase in the total testosterone levels at week 12 (p < 0.05) in the Physta® 100 mg group and from weeks 4 (p < 0.05) in the 200 mg group compared to placebo. Changes in Ageing Male Symptoms score and Fatigue Severity Scale score were significantly reduced (p < 0.001) regarding the total scores within- and between-group in both Physta® groups. DHEA levels significantly increased (p < 0.05) within-group in both Physta® groups from week 2 onwards. Cortisol levels significantly (p < 0.01) decreased in the Physta® 200 mg group, while muscle strength significantly (p < 0.001) increased in both Physta® groups at week 12 compared to baseline. No safety related clinically relevant changes were observed. Authors concluded that supplementation of Physta® at 200 mg was able to increase the serum total testosterone, reduce fatigue and improve the quality of life in ageing men.

Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study. Food Nutr Res. 2021 May 19;65. doi: 10.29219/fnr.v65.5647. PMID: 34262417; PMCID: PMC8254464.

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