This randomized, triple-blind, placebo-controlled, clinical trial was conducted to evaluate the renal-stone-dissolving efficacy of black seed supplementation in patients with renal stones.
To do so, 60 patients with renal stones were randomized to receive either 500 mg of black seed supplementation or placebo for 10 weeks. Patients were assessed in terms of size of renal stones by using sonography before and after intervention.
Results showed that a in the black seed group, 44.4% of patients excreted their stones completely, and the size of the stones remained unchanged and decreased in 3.7% and 51.8% of patients, respectively. The difference in the mean size of renal stones after the study was significant between the two groups (p < 0.05).
Therefore, Nigella sativa is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.
Ardakani Movaghati MR, Yousefi M, Saghebi SA, Sadeghi Vazin M, Iraji A, Mosavat SH. Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 2019 May;33(5):1404-1412. doi: 10.1002/ptr.6331. Epub 2019 Mar 14. PMID: 30873671.