- Peptides derived from certain probiotic strains exhibit a beneficial effect in the regulation of infection with the SARS-CoV-2 virus in silico
This study has evaluated the
effects in silico of different lipopetides from different probiotic
strains (subtilisin (Bacillus
amyloliquefaciens), curvacin A (Lactobacillus
curvatus), sakacin P (Lactobacillus
sakei), lactococcin Gb (Lactococcus
lactis)) on the inactivation of
spike (S) glycoprotein of SARS-CoV-2 and its host receptor molecule, ACE2.
The outcome revealed noteworthy
capabilities of the lipopeptides, due to their amphiphilic nature, to bind
spike protein and receptor molecule, ...
- Vitamin D for COVID-19: confirmation of the efficacy of supplementation
Vitamin
D is proposed as an effective solution of reducing the severity of COVID-19.
Some available evidences have already reported beneficial effects of vitamin D
supplementation. This new study examined the effects of vitamin D on the virus
clearance.
The
study was randomized and placebo-controlled. It has been conducted in
asymptomatic or mildly symptomatic patients with vitamin D deficiency. They
received 60000 IU ...
- Preclinical evaluation of baicalein supplementation for the management of SARS-CoV-2 infections
This preclinical study has evaluated the potential of baicalein, an active compound of Scutellaria baicalensis, for the management of COVID-19.
In vitro an inhibition of cellular damage induced
by SARS-CoV-2 has been demonstrated after exposure to at least 0.1 µM of
baicalein. According to in vivo
study, this concentration can be reached by supplementation with 200 mg/kg of
crystal ...
- Interest of botanicals for COVID-19
Curcuma
COVID‐19 is spreading worldwide, leading a pandemic. This review highlighted that curcumin could be a new treatment option to combat the COVID‐19. Curcumin, an active constituent of Curcuma longa (turmeric), has some useful clinical effects such as antiviral, antinociceptive, anti‐inflammatory, antipyretic, and antifatigue effects that could alleviate symptoms of the infected patient with COVID‐19. Curcumin ...
- Review of the effects of probiotics in stimulating the immune system in the context of viral respiratory tract infection
Viruses that cause respiratory
tract infections are found in various virus families, which differ in virulence
and utilize variable strategies to infect the host cells and to evade the host
immune system. Among non-pharmacological solutions for the management of these
respiratory tract infections, probiotics have been proposed as an adequate
solution. Indeed, probiotics have been shown to modulate immune system ...
- Review of the impact of probiotics in the antiviral response in the context of the COVID-19 epidemic
This review is based on the correlation that has been previously reported
between SRAS-CoV-2 disease progression and the composition of the gut
microbiota demonstrating that some
patients with COVID-19 showed intestinal microbial dysbiosis, with a decrease
in cell numbers of Lactobacillus and Bifidobacterium.
In this context, this review is
focused on the potential of probiotics
and their metabolites to intervene with ...
- Review of the effects of compounds present in Nigella sativa seeds in the prevention and management of viral infections such as SARS-CoV-2 infection
This review was interested in the potential
of active compounds from Nigella sativa
on the suppression of chronic inflammation and the promotion of healthy immune
response.
This review reported evidence of
beneficial effects of different Nigella
sativa preparations, mainly for preparation containing thymiquinone, alpha-hederin,
and nigellidine, against immune disturbance, autophagy
dysfunction, oxidative stress,
ischemia, inflammation, in several
COVID-19 comorbidities such as diabetes, cardiovascular disorders,
Kawasaki-like ...
- Folic acid status as a factor in SARS-CoV-2 infection
This study proposed a comparison of the amount of hospitalized pregnant women during the COVID-19
pandemic and the amount of hospitalized women during the 2009 A-H1N1 Pandemic.
Based on this comparison, authors
indicate that despite a greater susceptibility of pregnant women to different
infections in the case of SARS-CoV-2, they appear to be protected. Compared to
2009 H1N1 epidemic, the ...
- Interest of botanicals for COVID-19
For many years, medicinal plants have been used for the management of viral diseases. The new COVID-19 epidemic is devoid of any effective and widely accepted medication. One lead to identify effective treatment is therefore medicinal plants.
Some plants have already been shown to be effective against other respiratory viruses, as influenza virus, respiratory syncytial virus ...
- The most promising flavonoids against COVID-19
Numerous flavonoids were found to have antiviral effects against SARS-and MERS-CoV by mainly inhibiting the enzymes 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro).
This review is specifically focused on the search for flavonoids, polyphenolic compounds, which are proven to be effective against human CoVs. The latest progress in research to identify flavonoids for antiviral therapy ...
